Some people refer to antidepressant discontinuation syndrome as “antidepressant withdrawal.” The syndrome usually isn’t physically harmful, but it can be very unpleasant. In addition, stopping an antidepressant can make the condition it was treating (like depression or anxiety) come back. Stopping Lexapro (escitalopram) can lead to various withdrawal symptoms, such as insomnia, nausea, irritability, and headaches. Stopping gradually can help prevent withdrawal effects. Stopping Lexapro too quickly can cause withdrawal symptoms. Learn how to taper safely, what to expect, and how to tell withdrawal from relapse. Patients who stop their antidepressants are at risk for the discontinuation syndrome, especially if they abruptly stop the drug, taper it too quickly, or switch to a new antidepressant with a different pharmacodynamic profile [1-6]. Learn the symptoms of Lexapro withdrawal, why they happen, what to expect during tapering and when to seek professional support for safer recovery. Does Lexapro cause withdrawal symptoms? Studies show that between 20-85% of individuals stopping an antidepressant medication, such as Lexapro (escitalopram), experience withdrawal symptoms. When I came off Lexapro the last time I was taking it, I did not notice any significant withdrawal symptoms if any. I had only been on it for about a year at that time at 10 mg a day. Evidence-based Lexapro (escitalopram) tapering guide. Withdrawal timeline, tapering protocol, community tips, and SSRI deprescribing info. Withdrawal from Lexapro isn’t always easy. Here's what you need to know about Lexapro withdrawal symptoms, the timeline of the symptoms, and how to get help. Lexapro withdrawal symptoms are most often described as flu-like symptoms, such as nausea, dizziness, fatigue, fever, headache, trouble sleeping, and mood swings. The safest way to safely stop taking Lexapro, or any other antidepressant, is to do so under the direct supervision of your doctor.